Notes:
- The Arizona Cardinals snapped a two-game losing streak by defeating the San Francisco 49ers 33-21.
- The Washington Redskins advanced to 3-2 with a 16-10 victory over the Baltimore Ravens.
- New England Patriots quarterback Tom Brady made his 2016 regular season debut as the Pats trounced the Cleveland Browns 33-13.
- The Philadelphia Eagles sunk to 3-1 with a 24-23 loss to the Detroit Lions.
- The Indianapolis Colts edged the Chicago Bears 29-23.
- The Tennessee Titans defeated the Miami Dolphins 30-17.
- The Minnesota Vikings defeated the Houston Texans 31-13, and are the NFL’s only unbeaten team through Week Five.
- The Pittsburgh Steelers defeated the New York Jets 31-13.
- The Denver Broncos lost their first game of the season to the Atlanta Falcons 23-16.
- The Dallas Cowboys defeated the Cincinnati Bengals 28-14.
- The Buffalo Bills’ 30-19 victory over the Los Angeles Rams marked their third straight win.
- The San Diego Chargers stumbled to 1-4 with a 34-31 loss to the Oakland Raiders.
- The Green Bay Packers defeated the New York Giants 23-16.
- The Carolina Panthers fell to 1-4 with a 17-14 loss to the Tampa Bay Buccaneers.